MAL2 (gene)
Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.[1][2]
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.[2]
Interactions
MAL2 (gene) has been shown to interact with TPD52.[1]
References
- ↑ 1.0 1.1 Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (Sep 2001). “Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system”. Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
- ↑ 2.0 2.1 “Entrez Gene: MAL2 mal, T-cell differentiation protein 2”.
Further reading
- Marazuela M, Alonso MA (2004). “Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue”. Histol. Histopathol. 19 (3): 925–33. PMID 15168355.
- Rohan S, Tu JJ, Kao J, et al. (2007). “Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes”. Clin. Cancer Res. 12 (23): 6937–45. doi:10.1158/1078-0432.CCR-06-1268. PMID 17145811.
- Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). “Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations”. Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
- de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA (2006). “Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells”. Traffic. 7 (1): 61–73. doi:10.1111/j.1600-0854.2005.00361.x. PMID 16445687.
- Rual JF, Venkatesan K, Hao T, et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Llorente A, de Marco MC, Alonso MA (2005). “Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line”. J. Cell Sci. 117 (Pt 22): 5343–51. doi:10.1242/jcs.01420. PMID 15466889.
- Marazuela M, Acevedo A, García-López MA, et al. (2004). “Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia”. J. Histochem. Cytochem. 52 (2): 243–52. doi:10.1177/002215540405200212. PMID 14729876.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Marazuela M, Martín-Belmonte F, García-López MA, et al. (2004). “Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells”. Endocrinology. 145 (2): 1011–6. doi:10.1210/en.2003-0652. PMID 14576188.
- Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). “Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins”. J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- de Marco MC, Martín-Belmonte F, Kremer L, et al. (2002). “MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells”. J. Cell Biol. 159 (1): 37–44. doi:10.1083/jcb.200206033. PMC 2173496. PMID 12370246.
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