MOPP regimen

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Synonyms and keywords: Mechlorethamine/Prednisone/Procarbazine/Vincristine Regimen; MOPP; MOPP Regimen; MOPP regimen; Mustargen-Oncovin-Procarbazine-Prednisone Regimen; NM/PCB/PRED/VCR

Overview

MOPP regimen refers to a chemotherapy regimen consisting of mechlorethamine, vincristine (Oncovin), procarbazine and prednisone, used alone or in combination with radiation therapy for the treatment of stage I-IV Hodgkin lymphoma. Due to the increased risk of gonadal toxicity, this regimen has been widely replaced by the ABVD regimen.^[1]^[2]

Regimen

MMechlorethamine

OVincristine (Oncovin)

PProcarbazine

PPrednisone

Indications

Stage I-IV Hodgkin lymphoma^[1]^[3]

References

↑ ^1.0 ^1.1 Filatova LV, Plotnikova AA, Gershanovich ML, Semiglazova TIu (2013). “[Effectiveness and toxicity of MOPP, ABVD, BEACOPP chemotherapy in first-diagnosed Hodgkin lymphoma with a poor prognosis]”. Vopr Onkol. 59 (2): 59–65. PMID 23814851.
↑ “NCI Thesaurus”.
↑ “NCI Thesaurus”.

[pmid23814851-1] 1.0 ^1.1 Filatova LV, Plotnikova AA, Gershanovich ML, Semiglazova TIu (2013). “[Effectiveness and toxicity of MOPP, ABVD, BEACOPP chemotherapy in first-diagnosed Hodgkin lymphoma with a poor prognosis]”. Vopr Onkol. 59 (2): 59–65. PMID 23814851.

[2] “NCI Thesaurus”.

[3] “NCI Thesaurus”.

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