Marfan's syndrome natural history, complications and prognosis

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Editors-In-Chief: William James Gibson, C. Michael Gibson, M.S., M.D.

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [1] ; Assistant Editor-In-Chief: Cassandra Abueg, M.P.H. [2]

Overview

Prognosis

While patients now have nearly normal life expectancies, in previous decades, patients’ life expectancies were significantly shortened by the risks of aortic dissection, valvular failure and congestive heart failure. Together, these cardiovascular complications accounted for 90% of the mortality associated with Marfan syndrome such that in the 1970s, an affected individual would be expected to live only two-thirds as long as his unaffected counterparts ^[1].

References

↑ Murdoch JL, Walker BA, Halpern BL, Kuzma JW, McKusick VA (1972). “Life expectancy and causes of death in the Marfan syndrome”. The New England Journal of Medicine. 286 (15): 804–8. doi:10.1056/NEJM197204132861502. PMID 5011789. Retrieved 2010-12-22. Unknown parameter |month= ignored (help)

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[pmid5011789-1] Murdoch JL, Walker BA, Halpern BL, Kuzma JW, McKusick VA (1972). “Life expectancy and causes of death in the Marfan syndrome”. The New England Journal of Medicine. 286 (15): 804–8. doi:10.1056/NEJM197204132861502. PMID 5011789. Retrieved 2010-12-22. Unknown parameter |month= ignored (help)

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