Medulloblastoma classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Associate Editor(s)-in-Chief: Syed Musadiq Ali M.B.B.S.[3]
Overview
Medulloblastoma is classified into several subtypes based on the WHO histological classification system (classic vs. variant medulloblastoma) and the molecular subtypes classification system (WNT subgroup vs. SHH subgroup vs. Group 3 medulloblastoma vs. Group 4 medulloblastoma).[1][2][3][4][5]
Classification
WHO Histological Classification System
- Medulloblastoma is classified into two main subtypes based on the WHO histological classification system which include classic medulloblastoma and variant medulloblastoma.[2][4][5]
- Variant medulloblastoma may be further classified into desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic medulloblastoma, and medulloblastoma with extensive nodularity.
WHO histological classification system | |||||||||||||||||||||||||||||||||||||||
Classic medulloblastoma | Variant medulloblastoma | ||||||||||||||||||||||||||||||||||||||
Desmoplastic medulloblastoma | Large cell medulloblastoma | Anaplastic medulloblastoma | Medulloblastoma with extensive nodularity | ||||||||||||||||||||||||||||||||||||
Molecular Classification System
- Medulloblastoma may be classified into at least four major subgroup based on the molecular classification system which include WNT subgroup, SHH subgroup, Group 3, and Group 4.[1][3]
Molecular classification system | |||||||||||||||||||||||||||||||||||||||
WNT | SHH | Group 3 | Group 4 | ||||||||||||||||||||||||||||||||||||
WNT α WNT β | SHH α SHH β SHH γ | Group 3 α Group 3 β | Group 4 α Group 4 β | ||||||||||||||||||||||||||||||||||||
References
- ↑ 1.0 1.1 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T; et al. (2012). “Subgroup-specific structural variation across 1,000 medulloblastoma genomes”. Nature. 488 (7409): 49–56. doi:10.1038/nature11327. PMC 3683624. PMID 22832581.
- ↑ 2.0 2.1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). “The 2007 WHO classification of tumours of the central nervous system”. Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
- ↑ 3.0 3.1 Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
- ↑ 4.0 4.1 Medulloblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28 2015
- ↑ 5.0 5.1 Medulloblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28 2015
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