Microscopic polyangiitis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

There are no known direct causes for Microscopic polyangiitis. Microscopic polyangiitis can affect individuals from all ethnicities and of any age group.Vasculitis is a common term that refers to inflammation of the blood vessels in the body. When the inflammation progress it lead to weakening and stretch of the blood vessels and forms a an aneurysm.

Causes

Common Causes

There are no known direct common causes for Microscopic polyangiitis. However microscopic polyangiitis may be caused by:^[1]^[2]^[3]

Less Common Causes

Silica exposure
Malignancy

Genetic Causes

HLA-DRB1*09:01-DQB1*03:03 haplotype genes shows a significant increase in the association with Microscopic polyangiitis.^[4]
These haplotypes are mostly found in Japanese population.^[5]
Activation of NK/ T cells may also lead to predisposition to Microscopic polyangiitis.^[6]^[7]

References

↑ Kallenberg CG, Rarok A, Stegeman CA, Limburg PC (February 2002). “New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis”. Autoimmun Rev. 1 (1–2): 61–6. PMID 12849060.
↑ Hogan SL, Cooper GS, Savitz DA, Nylander-French LA, Parks CG, Chin H, Jennette CE, Lionaki S, Jennette JC, Falk RJ (March 2007). “Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study”. Clin J Am Soc Nephrol. 2 (2): 290–9. doi:10.2215/CJN.03501006. PMC 4049534. PMID 17699427.
↑ Tsuchiya N (2012). “Genetics of microscopic polyangiitis in the Japanese population”. Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
↑ Tsuchiya N (2012). “Genetics of microscopic polyangiitis in the Japanese population”. Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
↑ Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (January 2006). “Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese”. Genes Immun. 7 (1): 81–4. doi:10.1038/sj.gene.6364262. PMID 16208405.
↑ Naumova E, Mihaylova A, Stoitchkov K, Ivanova M, Quin L, Toneva M (February 2005). “Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals”. Cancer Immunol. Immunother. 54 (2): 172–8. doi:10.1007/s00262-004-0575-z. PMID 15248031.
↑ Miyashita R, Tsuchiya N, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (March 2006). “Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis”. Arthritis Rheum. 54 (3): 992–7. doi:10.1002/art.21653. PMID 16508981.

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[pmid12849060-1] Kallenberg CG, Rarok A, Stegeman CA, Limburg PC (February 2002). “New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis”. Autoimmun Rev. 1 (1–2): 61–6. PMID 12849060.

[pmid17699427-2] Hogan SL, Cooper GS, Savitz DA, Nylander-French LA, Parks CG, Chin H, Jennette CE, Lionaki S, Jennette JC, Falk RJ (March 2007). “Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study”. Clin J Am Soc Nephrol. 2 (2): 290–9. doi:10.2215/CJN.03501006. PMC 4049534. PMID 17699427.

[pmid235555272-3] Tsuchiya N (2012). “Genetics of microscopic polyangiitis in the Japanese population”. Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.

[pmid23555527-4] Tsuchiya N (2012). “Genetics of microscopic polyangiitis in the Japanese population”. Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.

[pmid16208405-5] Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (January 2006). “Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese”. Genes Immun. 7 (1): 81–4. doi:10.1038/sj.gene.6364262. PMID 16208405.

[pmid15248031-6] Naumova E, Mihaylova A, Stoitchkov K, Ivanova M, Quin L, Toneva M (February 2005). “Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals”. Cancer Immunol. Immunother. 54 (2): 172–8. doi:10.1007/s00262-004-0575-z. PMID 15248031.

[pmid16508981-7] Miyashita R, Tsuchiya N, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (March 2006). “Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis”. Arthritis Rheum. 54 (3): 992–7. doi:10.1002/art.21653. PMID 16508981.

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