Minimal change disease risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

The cause of minimal change disease has not been identified or idiopathic. Nephrotic syndrome is most commonly as a result of damage to the clusters of tiny blood vessels (glomeruli).But secondary causes may be due to Drugs, Toxins, Infection, and Tumor.

Common risk factors in the development of minimal change disease include:^[1]

Children within the Age >1 year and <8 years
Hodgkin lymphoma
leukemia
Recent viral illness
Toxins such as Mercury, bee stings, fire coral exposure are one of the causes for minimal change disease.
Medications such as:^[2]
- Salazopyrin
- Mercury
- Tiopronin
- Lithium
- D-penicillamine
- Gold
- Tyrosine-kinase inhibitor

Less common causes of minimal change disease include:^[3]^[4]

↑ Iijima, Kazumoto; Hamahira, Kiyoshi; Tanaka, Ryojiro; Kobayashi, Akiko; Nozu, Kandai; Nakamura, Hajime; Yoshikawa, Norishige (2002). “Risk factors for cyclosporine-induced tubulointerstitial lesions in children with minimal change nephrotic syndrome”. Kidney International. 61 (5): 1801–1805. doi:10.1046/j.1523-1755.2002.00303.x. ISSN 0085-2538.
↑ Vivarelli M, Massella L, Ruggiero B, Emma F (February 2017). “Minimal Change Disease”. Clin J Am Soc Nephrol. 12 (2): 332–345. doi:10.2215/CJN.05000516. PMC 5293332. PMID 27940460.
↑ Vivarelli M, Massella L, Ruggiero B, Emma F (February 2017). “Minimal Change Disease”. Clin J Am Soc Nephrol. 12 (2): 332–345. doi:10.2215/CJN.05000516. PMC 5293332. PMID 27940460.
↑ Vivarelli, Marina; Massella, Laura; Ruggiero, Barbara; Emma, Francesco (2017). “Minimal Change Disease”. Clinical Journal of the American Society of Nephrology. 12 (2): 332–345. doi:10.2215/CJN.05000516. ISSN 1555-9041.