Mucoepidermoid carcinoma surgery

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] , Maria Fernanda Villarreal, M.D. [3]

Surgery is the mainstay of therapy for mucoepidermoid carcinoma.

• Mucoepidermoid carcinoma (low-grade): complete surgical excision with sparing of the facial nerve.^[1][1]
• Mucoepidermoid carcinoma (high-grade): parotidectomy with facial nerve sparing may be followed by radiotherapy.
• Clinically aggressive mucoepidermoid carcinoma tumors with facial nerve involvement will require radical surgery with sacrifice of the facial nerve and radiotherapy. ^[2]
• Primary nerve grafting using the sural nerve if possible is performed.
• Lymph node dissection is usually only performed for detected nodal metastasis.

• Low grade mucoepidermoid carcinoma in the floor of the mouth can be surgically excised along with involved lymph node.^[3][4]

• When the tumor is at an inaccessible location, clinical trial therapies (especially for stage IV disease) including:
  • Therapeutic drugs
  • Radiation
  • Stem cell transplantation
  • Monoclonal antibodies
• Either singly or in combination of various therapies

• Follow-up care with regular screening and check-ups are important^[5]

• Indications for surgery for mucoepidermoid carcinoma, include:^[6]

• Biological and histological features suitable for surgery

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