Mycobacterium intracellulare

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Mycobacterium intracellulare

Gram-positive, nonmotile and acid-fast short to long rods.

Colony characteristics

• Usually smooth, rarely rough and nonpigmented colonies. Ageing colonies may become yellow.

Physiology

• Growth on Löwenstein-Jensen medium and Middlebrook 7H10 at 37°C after 7 or more days.
• Resistant to isoniazid, ethambutol, rifampin and streptomycin.

Differential characteristics

• M. intracellulare and M. avium form the M. avium-intracellulare complex (MAIC). A commercially available hybridisation assay (AccuProbe) to identify all members of the MAIC exists. Furthermore, separate AccuProbes are available to identify either M. intracellulare or M. avium.
• remarkable ITS heterogeneity within different M. intracellulare isolates.

• Most frequently encountered in pulmonary secretions from patients suffering from tuberculosis like disease and from surgical specimens from such patients.
• When isolated from human secretions, it is often the etiologic agent of pulmonary disease, although frequently isolated as apparent casual resident
• Biosafety level 2

• First isolated from fatal systemic disease in a child. Found in soil and water.

Strain ATCC 13950 = CCUG 28005 = CIP 104243 = DSM 43223 = JCM 6384 = NCTC 13025.

• Cuttino, J., A. McCabe. 1949. Pure granulomatous nocardiosis: A new fungus disease distinguished by intracellular parasitism. American Journal of Clinical Pathology, 25, 1-34.
• Runyon, E. 1965. Pathogenic mycobacteria. Advances in Tuberculosis Research, 14, 235-287.

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