Myxoma laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Maria Fernanda Villarreal, M.D. [3]

Overview

Laboratory findings consistent with cardiac myxoma include anemia, leukocytosis, and elevated erythrocyte sedimentation rate. However, these results are generally non-diagnostic.

Laboratory Findings

The clinical utility of laboratory tests in the diagnosis of cardiac myxoma remains nonspecific. Laboratory findings consistent with cardiac myxoma include anemia, leukocytosis and elevated erythrocyte sedimentation rate.^[1]

Blood tests

There is no specific blood test for the diagnosis of cardiac myxoma. However, constitutional symptoms are associated with the following cell blood count (CBC) findings:^[2]

Anemia – Normochromic or hypochromic
Leukocytosis
Elevated erythrocyte sedimentation rate (ESR)
Elevated C-reactive protein
Serum globulin level (hypergammaglobulinemia):
- A1-globulin serum levels can be found in patients with cardiac myxoma, and have been proposed as predictive markers of embolic accidents. ^[3]
Serum IL-6:
- Atrial myxoma cells are capable of producing Interleukin-6 (IL-6). Consequently, IL-6 is used as a marker of recurrence in cardiac myxomas.^[4]

References

↑ Reynen K (1995). “Cardiac myxomas”. N. Engl. J. Med. 333 (24): 1610–7. doi:10.1056/NEJM199512143332407. PMID 7477198.
↑ Hartig I, Kraatz EG, Beurich HW, Moosig F (2014). “[Atrial myxoma with clinical signs of systemic inflammatory disease.]”. Z Rheumatol. doi:10.1007/s00393-013-1347-y. PMID 24599357.
↑ Jelic J, Milicić D, Alfirević I, Anić D, Baudoin Z, Bulat C, Corić V, Dadić D, Husar J, Ivanćan V, Korda Z, Letica D, Predrijevac M, Ugljen R, Vućemilo I (1996). “Cardiac myxoma: diagnostic approach, surgical treatment and follow-up. A twenty years experience”. J Cardiovasc Surg (Torino). 37 (6 Suppl 1): 113–7. PMID 10064362.
↑ Ezerioha N, Feng W (2015). “Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6”. Case Rep Neurol. 7 (2): 152–5. doi:10.1159/000437256. PMC 4560324. PMID 26351445.

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[pmid7477198-1] Reynen K (1995). “Cardiac myxomas”. N. Engl. J. Med. 333 (24): 1610–7. doi:10.1056/NEJM199512143332407. PMID 7477198.

[pmid24599357-2] Hartig I, Kraatz EG, Beurich HW, Moosig F (2014). “[Atrial myxoma with clinical signs of systemic inflammatory disease.]”. Z Rheumatol. doi:10.1007/s00393-013-1347-y. PMID 24599357.

[pmid10064362-3] Jelic J, Milicić D, Alfirević I, Anić D, Baudoin Z, Bulat C, Corić V, Dadić D, Husar J, Ivanćan V, Korda Z, Letica D, Predrijevac M, Ugljen R, Vućemilo I (1996). “Cardiac myxoma: diagnostic approach, surgical treatment and follow-up. A twenty years experience”. J Cardiovasc Surg (Torino). 37 (6 Suppl 1): 113–7. PMID 10064362.

[pmid26351445-4] Ezerioha N, Feng W (2015). “Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6”. Case Rep Neurol. 7 (2): 152–5. doi:10.1159/000437256. PMC 4560324. PMID 26351445.

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