Neurofibroma historical perspective
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
NF1-like cutaneous tumor syndromes appeared in the literature in 1880s, when Friedrich von Recklinghausen published seminal observations detailing cutaneous tumors comprised of both neuronal and fibroblastic tissue finally termed as neurofibromas. In 2006, Yang et al demonstrated a critical neurofibroma microenvironment interaction that includes SCF–stimulated Nf1+/− mast cells potentiating Nf1+/− fibroblast functions.
Historical Perspective
- In 18th century, NF1-like cutaneous tumor syndromes appeared in the literature.[1]
- In 1880s, Friedrich von Recklinghausen published seminal observations detailing cutaneous tumors comprised of both neuronal and fibroblastic tissue finally termed as neurofibromas.
- In 2006, Yang et al demonstrated a critical neurofibroma microenvironment interaction that includes SCF–stimulated Nf1+/− mast cells potentiating Nf1+/− fibroblast functions.[2]
References
- ↑ Morse RP (1999). “Neurofibromatosis type 1”. Arch Neurol. 56 (3): 364–5. PMID 10190829.
- ↑ Staser, Karl; Yang, Feng-Chun; Clapp, D. Wade (2010). “Mast cells and the neurofibroma microenvironment”. Blood. 116 (2): 157–164. doi:10.1182/blood-2009-09-242875. ISSN 0006-4971.
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