Neurofibroma surgery
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]
Overview
Surgery is the mainstay of treatment for neurofibroma. Localized and diffuse lesions are usually treated surgically. Neurofibromas that infiltrate between nerve fascicles are unable to be separated from the parent nerve, therefore, deep-seated lesions are often managed conservatively. Local recurrence after excision is uncommon .and malignant transformation occurs rarely.
Surgery
Localised neurofibroma and Diffuse neurofibroma (not associated with NF-1)
- Localized and diffuse lesions are usually treated surgically[1]
- Neurofibromas that infiltrate between nerve fascicles are unable to be separated from the parent nerve, therefore, deep-seated lesions are often managed conservatively
- Local recurrence after excision is uncommon
- malignant transformation occurs rarely
Plexiform neurofibroma (NF-1 associated)
- The primary treatment option for plexiform neurofibroma is not surgery, until and unless:
- Debilitating symptoms are present
- There is a possibility of malignant transformation[2][1]
- Removal of plexiform neurofibromas is difficult because they can be large and cross tissue boundaries hence, leading to incomplete resection
- Recurrence after resection is frequent
References
- ↑ 1.0 1.1 Neurofibroma. Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015
- ↑ Packer RJ, Gutmann DH, Rubenstein A, et al. (May 2002). “Plexiform neurofibromas in NF1: toward biologic-based therapy”. Neurology. 58 (10): 1461–70. doi:10.1212/wnl.58.10.1461. PMID 12041525.
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