No-reflow phenomenon historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Jennifer Giuseffi, M.D.; David M. Leder, M.D.; Ayokunle Olubaniyi, M.B,B.S [2]

Overview

This phenomenon was first described by Krug et al ^[1] during induced myocardial infarction in dog subjects in 1966, but the term ‘no-reﬂow’ was ﬁrst used by Majno and colleagues in 1967 when they observed that brains of rabbits exposed to prolonged ischemia suffered significant changes in the microvasculature which impeded blood flow to the brain cells.

References

↑ Krug, A.; Du Mesnil de Rochemont, G.; Korb, . (1966). “Blood supply of the myocardium after temporary coronary occlusion”. Circ Res. 19 (1): 57–62. PMID 5912914. Unknown parameter |month= ignored (help)

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[Krug-1966-1] Krug, A.; Du Mesnil de Rochemont, G.; Korb, . (1966). “Blood supply of the myocardium after temporary coronary occlusion”. Circ Res. 19 (1): 57–62. PMID 5912914. Unknown parameter |month= ignored (help)

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