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Non-alcoholic fatty liver disease physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]Parth Vikram Singh, MBBS[3]

Overview

Patients with NAFLD usually appear asymptomatic. Physical examination of patients with NAFLD is usually unremarkable.

Physical Examination

Patients with NAFLD usually appear asymptomatic. Physical examination of patients with NAFLD is usually unremarkable.[1]

Approximately 50% to 60% of patients with MASLD have mild to moderate hepatomegaly, while less than 5% have splenomegaly. More than 80% of patients are overweight or obese, 60% to 70% have atherogenic dyslipidemia, approximately 60% have prediabetes or type 2 diabetes, and up to 50% have hypertension.[2]

References

  1. “Nonalcoholic Fatty Liver Disease: Diagnosis and Management – American Family Physician”.
  2. Tilg H, Petta S, Stefan N, Targher G (January 2026). “Metabolic Dysfunction-Associated Steatotic Liver Disease in Adults: A Review”. JAMA. 335 (2): 163–174. doi:10.1001/jama.2025.19615. PMID 41212550 Check |pmid= value (help).

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