Oligoastrocytoma other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Other diagnostic studies for oligoastrocytoma include biopsy (“star-shaped” astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).

Other Diagnostic Studies

Biopsy

Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.^[1]
On biopsy, oligoastrocytoma is characterized by “star-shaped” astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.
Biopsy may be done at the time of surgical resection of oligoastrocytoma.
Biopsy may be of two types: open and stereotactic.
Indications for open biopsy and stereotactic biopsy are described below:^[2]


Type of biopsy	Indications

Open biopsy	Surgically resectable masses Lesions in accessible and relatively “silent” areas of the brain or in areas of the brain with a mild postoperative neurologic deficit Appearance consistent with tumor on the MRI Large tumors exerting mass effect
Stereotactic biopsy	Deep-seated tumor that is not amenable to resection Lesions in which the radiological and clinical findings are ambiguous Diffuse or multiple lesions Appearance that suggests a lymphoma, which would not require resection Change in the appearance of a previously diagnosed or treated tumor Assessment of tumor after treatment (to distinguish between radiation necrosis and tumor recurrence)

Fluorescent in-situ hybridization (FISH) technique

30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of 1p and 19q.^[3]
FISH demonstrates deletions of chromosome 1p and 19q.^[4]^[5]

References

↑ Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015
↑ Eskandar EN, Loeffler JS, O’Neill AM, Hunter GJ, Louis DN (2004). “Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion”. N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
↑ Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). “Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets”. Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
↑ Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 20 October, 2015 Check date values in: |accessdate= (help)
↑ Smith JS, Perry A, Borell TJ, Lee HK, O’Fallon J, Hosek SM; et al. (2000). “Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas”. J Clin Oncol. 18 (3): 636–45. PMID 10653879.

Template:WikiDoc Sources

[diagOAwiki-1] Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015

[pmid15509821-2] Eskandar EN, Loeffler JS, O’Neill AM, Hunter GJ, Louis DN (2004). “Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion”. N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.

[pmid12107116-3] Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). “Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets”. Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.

[turk-4] Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 20 October, 2015 Check date values in: |accessdate= (help)

[pmid10653879-5] Smith JS, Perry A, Borell TJ, Lee HK, O’Fallon J, Hosek SM; et al. (2000). “Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas”. J Clin Oncol. 18 (3): 636–45. PMID 10653879.

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