Oligodendroglioma epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]

Oligodendroglioma, although rare, is the third most common glioma. In adults, it constitutes about 9.4% of all primary brain and central nervous system tumors and 5%–18% of all glial neoplasms. The incidence of oligodendroglioma and anaplastic oligodendroglioma is estimated to be 0.32 and 0.17 cases per 100,000 individuals in the United States, respectively. Oligodendroglioma tends to affect the middle-aged adult population, most commonly occurring in the 4th and 5th decade of life. Median age at the time of diagnosis of oligodendroglioma is 35-47 years. Males are more commonly affected with oligodendroglioma than femaleswith male to female ratio being approximately 1.3:1. Oligodendroglioma usually affects individuals of the Caucasian race. African American, Latin American, and Asian individuals are less likely to develop oligodendroglioma.

• Oligodendroglioma, although rare, is the third most common glioma.^[1]
• It occurs primarily in adults constituting about 9.4% of all primary brain and central nervous system tumors and 5%–18% of all glial neoplasms.^[2]
• It can also be found in children comprising about 4% of all primary brain tumors.
• Oligodendroglioma and anaplastic oligodendroglioma, together are one-tenth as common as glioblastoma (most commonly occurring malignant primary brain tumor in adults).

• Incidence of oligodendroglioma and anaplastic oligodendroglioma is estimated to be 0.32 and 0.17 cases per 100,000 individuals in the United States, respectively.^[3][4]
• Approximately, 1000 oligodendroglial tumors are diagnosed each year in United States.

• Oligodendroglioma is a disease that tends to affect the middle-aged adult population (adults between 25 and 45 years of age).^[1]
• Oligodendroglioma most commonly occurs in the 4th and 5th decade of life.
• Median age at diagnosis of oligodendroglioma is 35-47 years.^[5]
• Median age at diagnosis is approximately 5 to 10 years older for World Health Organization (WHO) grade III (anaplastic) tumors compared with WHO grade II (low-grade) tumors.
• Oligodendroglioma is occasionally diagnosed in teenagers and in adults over the age of 65 years.^[6]

• Males are more commonly affected with oligodendroglioma than females.
• The male to female ratio is approximately 1.3:1.^[7]

• Oligodendroglioma usually affects individuals of the Caucasian race.
• African American, Latin American, and Asian individuals are less likely to develop oligodendroglioma.^[8]

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