Oligodendroglioma laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]

Some patients with oligodendroglioma may have elevated protein and cell count with normal glucose and lactate on CSF analysis, which is usually suggestive of hydrocephalus. Immunohistochemistry of oligodendrogliomas shows positive staining for IDH1-R132H, ATRX, GFAP, SOX10, MAP2, S-100, EMA, Ki-67, NSE, synaptophysin, OLIG1, and OLIG2, and negativestaining for p53, and keratins.

• Some patients with oligodendroglioma may have elevated protein and cell count with normal glucose and lactate on CSF analysis, which is usually suggestive of hydrocephalus.^[1][2]

• Oligodendrogliomas stain positive for:^{[3][4][5][6][7]}
  • IDH1-R132H (majority of cases)
  • ATRX
  • GFAP (positive in intermingled reactive astrocytes and minigemistocytes)
  • SOX10
  • MAP2
  • S-100
  • EMA
  • Ki-67
  • NSE
  • Synaptophysin
  • OLIG1
  • OLIG2
• Oligodendrogliomas stain negative for:
  • p53 (rare weakly positive cells can be seen)
  • Keratins (although cocktails may show cross reactivity)

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