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Oligodendroglioma other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]

Overview

Other diagnostic studies for oligodendroglioma include biopsy (homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).

Other Diagnostic Studies

Biopsy

Biopsy may be performed to help confirm the diagnosis of oligodendroglioma.
On biopsy, oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.^[1]
Biopsy may be done at the time of surgical resection of oligodendroglioma.
Biopsy may be of two types:
- Open biopsy
- Stereotactic biopsy
Indications for open biopsy and stereotactic biopsy are described below:^[2]

**Indications for different types of biopsies**
Type of biopsy	Indications
Open biopsy	Surgically resectable masses Lesions in accessible and relatively “silent” areas of the brain or in areas of the brain with a mild postoperative neurologic deficit Appearance consistent with tumor on the MRI Large tumors exerting mass effect
Stereotactic biopsy	Deep-seated tumor that is not amenable to resection Lesions in which the radiological and clinical findings are ambiguous Diffuse or multiple lesions Appearance that suggests a lymphoma, which would not require resection Change in the appearance of a previously diagnosed or treated tumor Assessment of tumor after treatment (to distinguish between radiation necrosis and tumor recurrence)

Fluorescent in-situ hybridization (FISH) technique

FISH demonstrates deletions of chromosome 1p and 19q.^[3]

References

↑ Wesseling P, van den Bent M, Perry A (2015). “Oligodendroglioma: pathology, molecular mechanisms and markers”. Acta Neuropathol. 129 (6): 809–27. doi:10.1007/s00401-015-1424-1. PMC 4436696. PMID 25943885.
↑ Eskandar EN, Loeffler JS, O’Neill AM, Hunter GJ, Louis DN (2004). “Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion”. N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
↑ Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 9 October, 2015 Check date values in: |accessdate= (help)

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