Optic nerve glioma causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
There is no established cause for optic nerve glioma.
Causes
- There is no established cause for optic nerve glioma.
- Sporadic pilocytic astrocytomas usually have a tandem duplication of chromosome 7q34 and associated BRAF-KIAA fusion gene.[1][2] Pilocytic astrocytomas associated with neurofibromatosis type 1 lack this fusion gene. However, it is unknown if the mutation in the BRAF-KIAA fusion gene in the setting of optic nerve glioma is the primary cause of the disease as it is in other pilocystic astrocytomas.
References
- ↑ Jacob K, Albrecht S, Sollier C, Faury D, Sader E, Montpetit A; et al. (2009). “Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours”. Br J Cancer. 101 (4): 722–33. doi:10.1038/sj.bjc.6605179. PMC 2736806. PMID 19603027.
- ↑ Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA; et al. (2009). “Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma”. Neurology. 73 (19): 1526–31. doi:10.1212/WNL.0b013e3181c0664a. PMC 2777068. PMID 19794125.
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