Oral cancer primary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2], Simrat Sarai, M.D. [3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]

Overview

Effective measures for the primary prevention of oral cancer include tobacco cessation, alcohol cessation, HPV vaccine, and avoiding excessive sun exposure.

Primary Prevention

Effective measures for the primary prevention of oral cancer include:^[1]
- Tobacco cessation^[2]
  - Based on solid evidence, cessation of exposure to tobacco (e.g., cigarettes, pipes, cigars, and smokeless tobacco) leads to a decrease in the risk of cancer of the oral cavity and oropharynx.
- Cessation of alcohol consumption^[3]
  - Based on fair evidence, cessation of alcohol consumption leads to a decrease in oral cavity cancer but not until approximately 10 years after cessation.
  - For cancer of the oropharynx, reduction in risk does not occur until approximately 20 years after cessation.
- Human papillomavirus (HPV) vaccine^[4]
  - Vaccination against HPV 16 and 18 has shown to prevent more than 90% of oral HPV 16/18 infections within 4 years of vaccination.
  - HPV-positive patients should be educated that their partners are at risk of developing cancer.
- Safe oral sex
- Avoiding excessive sun exposure

References

↑ Weyne J, Kazemi H, Leusen I (1976). “Mechanisms of CSF bicarbonate formation in normocapnia”. Arch. Int. Physiol. Biochim. 84 (4): 908–10. PMID 65979.
↑ Huber MA, Tantiwongkosi B (2014). “Oral and oropharyngeal cancer”. Med. Clin. North Am. 98 (6): 1299–321. doi:10.1016/j.mcna.2014.08.005. PMID 25443678.
↑ Altieri A, Bosetti C, Gallus S, Franceschi S, Dal Maso L, Talamini R, Levi F, Negri E, Rodriguez T, La Vecchia C (2004). “Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland”. Oral Oncol. 40 (9): 904–9. doi:10.1016/j.oraloncology.2004.04.005. PMID 15380168.
↑ Altieri A, Bosetti C, Gallus S, Franceschi S, Dal Maso L, Talamini R, Levi F, Negri E, Rodriguez T, La Vecchia C (2004). “Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland”. Oral Oncol. 40 (9): 904–9. doi:10.1016/j.oraloncology.2004.04.005. PMID 15380168.

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[pmid65979-1] Weyne J, Kazemi H, Leusen I (1976). “Mechanisms of CSF bicarbonate formation in normocapnia”. Arch. Int. Physiol. Biochim. 84 (4): 908–10. PMID 65979.

[pmid25443678-2] Huber MA, Tantiwongkosi B (2014). “Oral and oropharyngeal cancer”. Med. Clin. North Am. 98 (6): 1299–321. doi:10.1016/j.mcna.2014.08.005. PMID 25443678.

[pmid153801682-3] Altieri A, Bosetti C, Gallus S, Franceschi S, Dal Maso L, Talamini R, Levi F, Negri E, Rodriguez T, La Vecchia C (2004). “Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland”. Oral Oncol. 40 (9): 904–9. doi:10.1016/j.oraloncology.2004.04.005. PMID 15380168.

[pmid15380168-4] Altieri A, Bosetti C, Gallus S, Franceschi S, Dal Maso L, Talamini R, Levi F, Negri E, Rodriguez T, La Vecchia C (2004). “Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland”. Oral Oncol. 40 (9): 904–9. doi:10.1016/j.oraloncology.2004.04.005. PMID 15380168.

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