Ovarian cancer epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2] Huda A. Karman, M.D.

Ovarian cancer is the 7th most common type of cancer in women worldwide and the 8th most common type of cancer in the United States. Ovarian cancer is the second most common gynecologic malignancy and the most common cause of gynecologic cancer death in the United States. Ovarian cancer is the second most common gynecologic malignancy in developed countries, with an incidence of 9.4 per 100,000 women and a mortality rate of 5.1 per 100,000. In developing countries, it is the third most common gynecologic malignancy (cervical cancer is the most common), with an incidence of 5.0 per 100,000 and a mortality rate of 3.1 per 100,000. The age-adjusted prevalence of ovarian cancer in the United States is 71.3 per 100,000 in 2011. The estimated number of new cases of ovarian cancer is approximately 22,000.

• Ovarian cancer is more common in industrialized nations, with the exception of Japan. In the United States, females have a 1.4% to 2.5% (1 out of 40-60 women) lifetime chance of developing ovarian cancer.^[1][2]
• In the United States, the age-adjusted prevalence of ovarian cancer is 71.3 per 100,000 in 2011.^[3]

• The delay-adjusted incidence of ovarian cancer in 2011 was estimated to be 12.46 per 100,000 persons in the United States.^[3][4]

• In 2011, the age-adjusted incidence of ovarian cancer was 12.09 per 100,000 persons in the United States.^[3]

• Older women are at highest risk. More than half of the deaths from ovarian cancer occur in women between 55 and 74 years of age.

• While the overall age-adjusted incidence of ovarian cancer in the United States between 2007 and 2011 is 12.3 per 100,000, the age-adjusted incidence of ovarian cancer by age category is:^[3]
  • Under 65 years: 7.5 per 100,000
  • 65 and over: 45.2 per 100,000

• Shown below is an image depicting the delay-adjusted incidence and observed incidence of ovarian cancer by age and race in the United States between 1975 and 2011. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.^[3]

• Shown below is a table depicting the age-adjusted prevalence of ovarian cancer by race in 2011 in the United States.^[3]

• Shown below is an image depicting the incidence of ovarian cancer by race in the United States between 1975 and 2011.^[3]

API: Asian/Pacific Islander; AI/AN: American Indian/ Alaska Native

Among patients with histologically confirmed cases of ovarian cancer, the percent distribution of the types of the disease between 2007 and 2011 in the United States are:^[3]

• Carcinoma: 91.7%
  • Epidermoid carcinoma: 0.7%
  • Adenocarcinoma: 84%
    • Adenocarcinoma, not otherwise specified: 12.3%
    • Papillary adenocarcinoma: 1,5%
    • Clear cell adenocarcinoma: 5.2%
    • Endometrioid carcinoma: 9.7%
    • Cystadenocarcinoma, not otherwise specified: 0.4%
    • Serous cystadenocarcinoma: 20.9%
    • Papillary serous cystadenocarcinoma: 23.5%
    • Mucinous cystadenocarcinoma: 1.5%
    • Mucinous adenocarcinoma: 3.5%
    • Mucin-producing adenocarcinoma: 0.2%
    • Other adenocarcinoma: 5.3%
  • Other specific carcinoma: 2.3%
    • Stromal cell tumor: 1.6%
    • Other: 0.7%
  • Unspecified carcinoma, not otherwise specified: 4.6%
• Sarcoma and other soft tissues: 0.4%
• Other specific types: 6.9%
  • Mullerian mixed tumor: 3%
  • Malignant teratoma: 1.5%
  • Other: 2.4%
• Unspecified: 1.1%

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