Oxolinic acid
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s.[1][2] Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[3]
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References
- ↑ JP Patent 49138244
- ↑ Gleckman R, Alvarez S, Joubert DW, Matthews SJ (1979). “Drug therapy reviews: oxolinic acid”. American Journal of Hospital Pharmacy. 36 (8): 1077–9. PMID 384788. Unknown parameter
|month=ignored (help) - ↑ Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (1998). “Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor”. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 8 (4): 255–9. doi:10.1016/S0924-977X(97)00083-7. PMID 9928913. Unknown parameter
|month=ignored (help)
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