p27 (gene)

Overview

p27 is a human gene on chromosome 6 and belongs to the cip/kip family. It encodes a cell cycle inhibitor protein that binds to cyclin D and CDK4 and causes arrest in G1 phase. p27 is activated by Transforming Growth Factor β (TGF β). ^[1] A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. ^[2]

References

↑ p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 Hideo Toyoshima, Tony Hunter; Cell, Vol 78, 67-74, 15 July 1994
↑ Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1 Cell Press. , Vol 85, 721-732, 31 May 1996

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[1] 27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 Hideo Toyoshima, Tony Hunter; Cell, Vol 78, 67-74, 15 July 1994

[2] Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1 Cell Press. , Vol 85, 721-732, 31 May 1996

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