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PLATO bleeding criteria

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

PLATO Bleeding Classification ^[1]

“

1. Major Life-threatening:

Fatal
Intracranial
Intrapericardial with cardiac tamponade
Resulting in hypovolemic shock or severe hypotension that requires pressors or surgery
Clinically overt or apparent bleeding associated with decrease in hemoglobin >5 g/dL
Requiring transfusion of ≥4 U whole blood or PRBCs

Other Major

Significantly disabling (eg, intraocular with permanent vision loss)
Associated drop in hemoglobin of 3 to 5 g/dL
Requiring transfusion of 2 to 3 U whole blood or PRBCs

Any Major

Any one of the above criteria

2. Minor

Requiring medical intervention to stop or treat bleeding (e.g., epistaxis requiring visit to medical facility for packing)

3. Minimal

All others (e.g., bruising, bleeding gums, oozing from injection sites) not requiring intervention or treatment

”

References

↑ Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (2005). “Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients”. J Thromb Haemost. 3 (4): 692–4. doi:10.1111/j.1538-7836.2005.01204.x. PMID 15842354.

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