POEMS syndrome other imaging findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

Overview

(18)F-FDG PET/CT is an adequate tool for evaluation, diagnosis, and monitoring of the pathology. (18)F-FDG PET/CT may be helpful in the diagnosis of POEMS syndrome. Findings suggestive of POEMS syndrome include mixed bone lesions, lymphadenopathy, hepatosplenomegaly, and serous cavity effusions. Fluorescein angiography may reveal unilateral pooling of fluid consistent with cystoid macular edema. Optical coherence tomography (OCT) may show loss of retinal nerve fiber layer thickness.

Fluorescein angiography may reveal pooling of fluid consistent with cystoid macular edema.^[1]^[2]
Optical coherence tomography (OCT) may show loss of retinal nerve fiber layer thickness.^[2]
(18)F-FDG PET/CT is an adequate tool for evaluation, diagnosis, and monitoring of the pathology.^[3]
(18)F-FDG PET/CT may be helpful in the diagnosis of POEMS syndrome. Findings suggestive of POEMS syndrome include:
- Mixed bone lesions (lytic and sclerotic)^[4]^[3]
- Lymphadenopathy^[4]
- Hepatomegaly^[4]
- Splenomegaly^[4]
- Serous cavity effusions^[4]

↑ Okada K, Yamamoto S, Tsuyama Y, Mizunoya S (2007). “Case of POEMS syndrome associated with bilateral macular detachment resolved by autologous peripheral blood stem cell transplantation”. Jpn. J. Ophthalmol. 51 (3): 237–8. doi:10.1007/s10384-006-0428-8. PMID 17554492.
↑ ^2.0 ^2.1 Gutierrez-Ortiz C, Castro-Rebollo M, Pareja J, Beckford C, Teus M (2009). “Bilateral non-simultaneous optic neuropathy and unilateral macular edema in a patient with POEMS syndrome”. Eur J Ophthalmol. 19 (1): 166–9. PMID 19123170.
↑ ^3.0 ^3.1 Infante JR, García L, Rayo JI, Serrano J, Moreno M, Cobo A, Jimenez P, Martínez A (2019). “Positron Emission Tomography-Computed Tomography in a Case of POEMS Syndrome”. Indian J Nucl Med. 34 (1): 66–68. doi:10.4103/ijnm.IJNM_120_18. PMID 30713387.
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Pan Q, Li J, Li F, Zhou D, Zhu Z (September 2015). “Characterizing POEMS Syndrome with 18F-FDG PET/CT”. J. Nucl. Med. 56 (9): 1334–7. doi:10.2967/jnumed.115.160507. PMID 26182964.