Palmar plantar erythrodysesthesia physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D. [2]

Physical examination of patients with PPE depends on the grade of the disease. Determination of toxicity grading of PPE requires both visual assessment and patient description of symptoms. Skin findings include erythema, edema, hyperkeratosis, peeling, blisters, bleeding, and fissures.

Physical examination of patients with PPE depends on the grade of the disease. Determination of toxicity grading of PPE requires both visual assessment and patient description of symptoms.

• Patients with PPE usually appear normal.

• Vital signs of patients with PPE are usually normal.

• Skin examination of patients with PPE depends on the grade of the disease.
• Determination of toxicity grading of PPE requires both visual assessment and patient description of symptoms.

• Physical findings include:^[1]
  • Erythema
  • Edema
  • Hyperkeratosis
  • Peeling
  • Blisters
  • Bleeding
  • Fissures

• HEENT examination of patients with PPE is usually normal.

• Neck examination of patients with PPE is usually normal.

• Pulmonary examination of patients with PPE is usually normal.

• Cardiovascular examination of patients with PPE is usually normal.

• Abdominal examination of patients with PPE is usually normal.

• Back examination of patients with PPE is usually normal.

• Genitourinary examination of patients with PPE is usually normal.

• Neuromuscular examination of patients with PPE is usually normal.
• Rarely, sensory impairment in the extremities may be seen. ^{[2] [3]}

• Extremities examination, excluding the neuromuscular and skin findings, in patients with PPE is usually normal.