Pancreatic neuroendocrine tumor staging

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

The 2010 WHO classification of tumors of the digestive system grades all the neuroendocrine tumors into three categories, based on their degree of cellular differentiation (from well-differentiated “NET G1” through to poorly-differentiated “NET G3”). The NCCN recommends use of the same AJCC-UICC staging system as pancreatic adenocarcinoma. Using this scheme, the stage by stage outcomes for PanNETs are dissimilar to pancreatic exocrine cancers.^[1] A different TNM system for PanNETs has been proposed by The European Neuroendocrine Tumor Society.