Papillary thyroid cancer laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2] Sahar Memar Montazerin, M.D.[3]

Overview

Laboratory findings consistent with the diagnosis of papillary thyroid cancer include presence of tumor markers such as thyroglobulin. Thyroglobulin can be used as a tumor marker for well-differentiated papillary thyroid cancer.

Laboratory findings consistent with the diagnosis of papillary thyroid cancer include presence of tumor markers such as thyroglobulin. Thyroglobulin can be used as a tumor marker for well-differentiated papillary thyroid cancer.^[1]^[2]
Reduced expression of ATP5E is significantly associated with the diagnosis of papillary thyroid cancer and may serve as an early tumor marker of the disease.^[3]
Thyroid cancer rarely affects thyroid endocrine function. Therefore, thyroid function test is not diagnostic for the papillary thyroid cancer.^[4]

↑ Lin JD (2007). “Thyroglobulin and human thyroid cancer”. Clin Chim Acta. 388 (1–2): 15–21. doi:10.1016/j.cca.2007.11.002. PMID 18060877.
↑ Tuttle RM, Leboeuf R, Martorella AJ (2007). “Papillary thyroid cancer: monitoring and therapy”. Endocrinol. Metab. Clin. North Am. 36 (3): 753–78, vii. doi:10.1016/j.ecl.2007.04.004. PMID 17673127.
↑ Hurtado-López, LM; Fernández-Ramírez, F; Martínez-Peñafiel, E; Carrillo Ruiz, JD; Herrera González, NE (16 June 2015). “Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?”. Medical science monitor : international medical journal of experimental and clinical research. 21: 1745–51. PMID 26079849.
↑ DeLellis, Ronald (2004). Pathology and genetics of tumours of endocrine organs. Lyon: IARC Press. ISBN 92-832-2416-7.