Paramethadione
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.[1]
Chemistry
Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.
- M.A. Spielman, Template:US Patent (1951).
References
- ↑ Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes – Retrieved January 2007.
External links
- Template:DiseasesDB
- Hoffman, D; Chun A (1975). “Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose”. J Pharm Sci. 64 (10): 1702–1703. doi:10.1002/jps.2600641027. PMID 1185541.
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