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Parathyroid adenoma historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]

Overview

The oldest known case of hyperparathyroidism was found in a cadaver from a Early Neolithic cemetery in southwest Germany. In 1880, Ivar Sandström, a Swedish anatomist, described parathyroids in human following 50 autopsies. He found two parathyroid glands bilaterally in 43 out of 50 autopsies. In 1925, Felix Mandl, a viennese surgeon, was the first who performed parathyroidectomy to treat a patient suffering from osteitis fibrosa cystica.

Historical Perspective

Discovery

  • The oldest known case of hyperparathyroidism was found in a cadaver from a Early Neolithic cemetery in southwest Germany.[1]
  • In 1852, Sir Richard Owen, Hunterian Professor and Conservator of the Museum in the Royal College of Surgeons of England, described parathyroids in rhinoceros.[2]
  • In 1880, Ivar Sandström, a Swedish anatomist, described parathyroids in human following 50 autopsies. He found two parathyroid glands bilaterally in 43 out of 50 autopsies.[3]
  • In 1891, Friedrich van Rechlinghausen, a German pathologist described ‘osteitis fibrosa cystica‘ (the parathyroid cystic bone disease).[3]

Landmark Events in the Development of Treatment Strategies

Famous Cases

  • Garry Shandling, a famous comedian suffered from hyperparathyroidism.[5]

References

  1. Zink AR, Panzer S, Fesq-Martin M, Burger-Heinrich E, Wahl J, Nerlich AG (2005). “Evidence for a 7000-year-old case of primary hyperparathyroidism”. JAMA. 293 (1): 40–2. doi:10.1001/jama.293.1.40-c. PMID 15632333.
  2. Modarai B, Sawyer A, Ellis H (2004). “The glands of Owen”. J R Soc Med. 97 (10): 494–5. doi:10.1258/jrsm.97.10.494. PMC 1079622. PMID 15459265.
  3. 3.0 3.1 Johansson H (2015). “The Uppsala anatomist Ivar Sandström and the parathyroid gland”. Ups. J. Med. Sci. 120 (2): 72–7. doi:10.3109/03009734.2015.1027426. PMC 4463479. PMID 25913489.
  4. Thompson, Scott M.; Thompson, Geoffrey B. (April 8, 2015). Felix Mandl. Surgical Endocrinopathies. p. 153-156. ISBN 978-3-319-13661-5.
  5. “Garry Shandling and the Disease You Didn’t Know About – The Atlantic”.

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