Paroxysmal nocturnal hemoglobinuria classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Paroxysmal nocturnal hemoglobinuria may be classified according to the diagnosis results into three subtypes. The subtypes of PNH include classic PNH, secondary PNH, or subclinical PNH.

Classification

Paroxysmal nocturnal hemoglobinuria may be classified according to diagnosis results into three subtypes:^[1]^[2]

Classic PNH: Other bone marrow disorders with a confirmed diagnosis of PNH.
Secondary PNH: When PNH is due to other bone marrow disorder as aplastic anemia or myelodysplastic syndrome.
Subclinical PNH: No signs or symptoms of PNH, however, flow cytometry shows results of PNH.

References

↑ Mok WM, Herschkowitz S, Krieger NR (1991). “In vivo studies identify 5 alpha-pregnan-3 alpha-ol-20-one as an active anesthetic agent”. J Neurochem. 57 (4): 1296–301. PMID 1895106  Check |pmid= value (help).
↑ Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). “Diagnosis and management of paroxysmal nocturnal hemoglobinuria”. Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.

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[pmid1895106-1] Mok WM, Herschkowitz S, Krieger NR (1991). “In vivo studies identify 5 alpha-pregnan-3 alpha-ol-20-one as an active anesthetic agent”. J Neurochem. 57 (4): 1296–301. PMID 1895106  Check |pmid= value (help).

[pmid16051736-2] Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). “Diagnosis and management of paroxysmal nocturnal hemoglobinuria”. Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.

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