Paroxysmal nocturnal hemoglobinuria other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief:

Overview

Fluorescent aerolysin (FLAER) can be used to diagnose There are no other diagnostic studies associated with paroxysmal nocturnal hemoglobinuria.

Other Diagnostic Studies

Fluorescent aerolysin (FLAER) can be used to diagnose paroxysmal nocturnal hemoglobinuria.^[1] This test is based on the idea that FLAER binds to GPI anchors. In the absence of GPI anchors on the cell membrane, FLAER will not bind, so PNH cells are negative for FLAER.

References

↑ Brodsky RA (2008). “Advances in the diagnosis and therapy of paroxysmal nocturnal hemoglobinuria”. Blood Rev. 22 (2): 65–74. doi:10.1016/j.blre.2007.10.002. PMC 2290854. PMID 18063459.

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[pmid18063459-1] Brodsky RA (2008). “Advances in the diagnosis and therapy of paroxysmal nocturnal hemoglobinuria”. Blood Rev. 22 (2): 65–74. doi:10.1016/j.blre.2007.10.002. PMC 2290854. PMID 18063459.

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