Paternal age effect

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753

The paternal age effect describes the influence that a father’s age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men do. This is seen as likely due to genetic copying errors which may increase in number after repeated spermatogenesis cycles over a man’s lifetime.

Achondroplasia (dwarfism); craniofacial disorders such as Apert syndrome and Crouzon Syndrome; mental retardation of unknown etiologies; autism; and 25% of schizophrenia cases are correlated with advanced paternal age.

Other disorders related to advanced paternal age are:

• Wilms’ tumor
• Thanatophoric dysplasia
• Retinitis pigmentosa
• Osteogenesis imperfecta type IIA
• Acrodysostosis
• Fibrodysplasia ossificans progressiva
• Aniridia
• Bilateral retinoblastoma
• Multiple exostoses
• Marfan Syndrome
• Lesch-Nyhan syndrome
• Pfeiffer Syndrome
• Wardenburg Syndrome
• Treacher-Collins Syndrome
• Soto’s basal cell nevus
• Cleidocranial dysostosis
• Polyposis coli
• Oculodentodigital syndrome
• Costello syndrome
• Progeria
• Recklinghausen’s neurofibromatosis
• Tuberous sclerosis
• Polycystic kidney disease
• Hemophilia A
• Duchenne muscular dystrophy
• Athetoid Cerebral Palsy
• Dystonic Cerebral Palsy
• Congenital Hemiplegia

• Maternal age effect

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• Paternal+age at the US National Library of Medicine Medical Subject Headings (MeSH)

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