Peptic ulcer epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

The incidence and prevalence of Helicobacter pylori infection are generally higher among people born outside North America. Within North America, the prevalence of the infection is higher in certain racial and ethnic groups, and people who have immigrated to North America. Peptic ulcer disease is acquired during childhood. The incidence of Peptic ulcer disease increases with age; the median age at diagnosis is 18-30 years. Peptic ulcer disease affects both sexes equally in childhood. Men are more commonly affected by peptic ulcer disease than women in adulthood.

• The incidence of peptic ulcer disease is approximately 10-19 per 100,000 individuals worldwide^[1]
• In 2011, the incidence rate of peptic ulcer disease was estimated to be one case per 1000 individuals and its complications was 0.7 per 1000 individuals^[2]
• The incidence and prevalence of Helicobacter pylori infection are generally higher among people born outside North America. Within North America, the prevalence of the infection is higher in certain racial and ethnic groups, and people who have immigrated to North America^[3]

• The prevalence of peptic ulcer disease is approximately 23.1 per 100,000 individuals but higher in men 29.4 per 100,000 than women 14.9 per 100,000
• The prevalence of peptic ulcer disease is estimated to be 4.5 million cases annually
• Lifetime prevalence is 11-14% in men and 8-11% in women^{[4][5][1][6][7][8][9][10]}

• The mortality rate of peptic ulcer disease is approximately 1 per 100,000 individuals

• Peptic ulcer disease is acquired during childhood
• The incidence of Peptic ulcer disease increases with age; the median age at diagnosis is 18-30 years

• Peptic ulcer disease usually affects individuals of the African Americans with a higher proportion of African ancestry race and Mexican Americans^[11][12]
• Non-Hispanic whites individuals are less likely to develop the peptic ulcer disease

• Peptic ulcer disease affect equally in childhood^[13]
• Men are more commonly affected by peptic ulcer disease than women in adulthood^[5]

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