Peutz-Jeghers syndrome surgery

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]

Overview

Surgery is the mainstay of treatment for Peutz-Jeghers syndrome. Surgical options include polypectomy, laparotomy in case of intussusception, and laser cosmetic therapy may be considered for mucocutaneous pigmentation.

Indications

Indications for surgery are as follows:^[1]^[2]

Copious rectal bleeding
Intussusception
Polyps greater than 1-1.5 cm in size
Rapidly growing polyps The types of surgical procedures are as follows:

Surgery

The surgical procedures are as follows:^[3]

Polypectomy:
- Forcep biopsy polypectomy
- Snare polypectomy
Endoscopic mucosal resection
Endoscopic submucosal resection
Laparotomy and desvagination of intestinal loops may be needed in case of intussusception.
Laser cosmetic therapy may be considered for mucocutaneous pigmentation.

References

↑ Giardiello, F; Trimbath, J (2006). “Peutz-Jeghers Syndrome and Management Recommendations”. Clinical Gastroenterology and Hepatology. 4 (4): 408–415. doi:10.1016/j.cgh.2005.11.005. ISSN 1542-3565.
↑ Hofmann S, Barth TF, Kornmann M, Henne-Bruns D (2014). “Appendix carcinoid associated with the Peutz-Jeghers syndrome”. Int J Surg Case Rep. 5 (12): 964–7. doi:10.1016/j.ijscr.2014.06.024. PMC 4276270. PMID 25460448.
↑ Repici, Alessandro; Anderloni, Andrea; Jovani, Manol; Hassan, Cesare (2014). “Advances, problems, and complications of polypectomy”. Clinical and Experimental Gastroenterology: 285. doi:10.2147/CEG.S43084. ISSN 1178-7023.

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[GiardielloTrimbath2006-1] Giardiello, F; Trimbath, J (2006). “Peutz-Jeghers Syndrome and Management Recommendations”. Clinical Gastroenterology and Hepatology. 4 (4): 408–415. doi:10.1016/j.cgh.2005.11.005. ISSN 1542-3565.

[pmid25460448-2] Hofmann S, Barth TF, Kornmann M, Henne-Bruns D (2014). “Appendix carcinoid associated with the Peutz-Jeghers syndrome”. Int J Surg Case Rep. 5 (12): 964–7. doi:10.1016/j.ijscr.2014.06.024. PMC 4276270. PMID 25460448.

[RepiciAnderloni2014-3] Repici, Alessandro; Anderloni, Andrea; Jovani, Manol; Hassan, Cesare (2014). “Advances, problems, and complications of polypectomy”. Clinical and Experimental Gastroenterology: 285. doi:10.2147/CEG.S43084. ISSN 1178-7023.

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