Polyarthritis with joint swelling, fever, and weight loss

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

			Symptoms				Physical examination			Lab Findings				Imaging			Histopathology
Diseases			Clinical manifestations							Para-clinical findings								Gold standard	Additional findings
			Symptoms				Physical examination			Para-clinical findings
			Joint Swelling	Fever	Weight loss	Claudication	Morning stiffness	Local erythema	Skin manifestation	CBC	ESR	Synovial fluid	Other	X-ray	CT scan	Other	Histopathology
Polyarthritis	Infectious arthritis	Lyme disease^[1]	+	+	+/-	+/-	–	–	Erythema migrans	Leukopenia, Thrombocytopenia	–	Cell counts 500-98,000/µL	Microscopic hematuria, Proteinuria, ↑ALT or AST	–	–	–	Fibrosis of the deeper dermis and hyalinization of collagen bundles	Serologic tests	Erythema migrans
Polyarthritis	Infectious arthritis	Bacterial endocarditis^[2]	+	+	+	–	–	+/-	Janeway lesions, Osler nodes, Roth spots	Normochromic-normocytic anemia	↑	↑WBC, S. aureus in culture	Hyperglobulinemia, Cryoglobulinemia	Joint erosion and effusion	–	–	Vegetation or intracardiac abscess demonstrating active endocarditis	Echocardiography (TTE)	Vertebral osteomyelitis
Polyarticular pain	Viral arthritis	Parvovirus^[3]	+	+	+/-	–	–	–	Fifth disease/ Erythema infectiosum	Aplastic crisis	↑	Normal	ANA, RF, CRP	Joint swelling	–	–	Immune complex deposition	Parvovirus IgM antibody	Transient aplastic crisis, Fetal infection

References

↑ Lantos PM (2015). “Chronic Lyme disease”. Infect Dis Clin North Am. 29 (2): 325–40. doi:10.1016/j.idc.2015.02.006. PMC 4477530. PMID 25999227.
↑ Soor P, Sharma N, Rao C (2017). “Multifocal Septic Arthritis Secondary to Infective Endocarditis: A Rare Case Report”. J Orthop Case Rep. 7 (1): 65–68. doi:10.13107/jocr.2250-0685.692. PMC 5458702. PMID 28630844.
↑ Moore TL (July 2000). “Parvovirus-associated arthritis”. Curr Opin Rheumatol. 12 (4): 289–94. PMID 10910181.