Post-streptococcal glomerulonephritis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Laboratory findings consistent with the diagnosis of streptococcal infection include antistreptolysin O (ASO) positive, antinicotinamide adenine dinucleotides positive, antihyaluronidase, and anti–DNAse B positive. Other abnormal laboratory findings include leukocytosis with neutrophilia, CRP is raised, increased levels of blood urea nitrogen (BUN) and serum creatinine levels are increased. On serologic testing, hypocomplementemia is usually found. On urinalysis, proteinuria, hematuria, and dysmorphic red cells are usually found.

• Diagnosis of preceding streptococcal infection can be determined by measuring following antibodies:^[1]
  • The antistreptolysin O (ASO) positive
  • Antinicotinamide adenine dinucleotides (anti-NAD) positive
  • Antihyaluronidase (AHase), and anti–DNAse B positive
• CBC with differential count:^[2]
  • Leukocytosis with neutrophilia
• CRP is raised
• Renal function tests:
  • Increased levels of blood urea nitrogen (BUN)
  • Serum creatinine levels are increased
• Serologic testing:^[3][4]
  • Hypocomplementemia such as low serum level of C3, C4, and C5.
• Urinalysis:^[5]
  • Proteinuria
  • Hematuria
  • Urine sediments show red blood cells, red blood cell casts, white blood cells, granular casts
  • Dysmorphic red blood cells are characteristics findings of glomerular hematuria

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