Pre-eclampsia causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Ogheneochuko Ajari, MB.BS, MS [3]
Overview
Common causes of preeclampsia include uteroplacental ischemia and genetic predisposition following the formation of atheromatous plaques and fibrinoid necrosis of the spiral vessel walls, oxidative stress in trophoblast cells, apoptosis in trophoblast cells,systemic inflammatory response, vasospasm, platelet aggregation, thrombin formation, deposition of the fibrin in multiple organs.
Causes
Common cause of preeclampsia include uteroplacental ischemia and genetic predisposition due to the following:[1][2]
- The formation of atheromatous plaques and fibrinoid necrosis of the spiral vessel walls
- Oxidative stress in trophoblast cells
- Apoptosis in trophoblast cells
- Systemic inflammatory response
- Vasospasm
- Platelet aggregation
- Thrombin formation
- Deposition of the fibrin in multiple organs
References
- ↑ Lye, P.; Bloise, E.; Dunk, C.; Javam, M.; Gibb, W.; Lye, S.J.; Matthews, S.G. (2013). “Effect of oxygen on multidrug resistance in the first trimester human placenta”. Placenta. 34 (9): 817–823. doi:10.1016/j.placenta.2013.05.010. ISSN 0143-4004.
- ↑ Mayrink, J.; Costa, M. L.; Cecatti, J. G. (2018). “Preeclampsia in 2018: Revisiting Concepts, Physiopathology, and Prediction”. The Scientific World Journal. 2018: 1–9. doi:10.1155/2018/6268276. ISSN 2356-6140.
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