Precocious puberty causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amira Albawri M.D.

Overview

Central precocious puberty may be caused by either

Central Precocious Puberty , Peripheral Precocious Puberty , or genetic .

Causes

Central Precocious Puberty

If the cause can be traced to the hypothalamus or pituitary, the cause is considered central.

Causes can include:

Damage to the inhibitory system of the brain (due to infection, trauma, or irradiation)
hypothalamic hamartoma produces pulsatile gonadotropin-releasing hormone (GnRH)
Langerhans cell histiocytosis
McCune-Albright syndrome
Intracranial neoplasm
Hydrocephalus
Angelman syndrome^[1]
Suprasellar arachnoid cysts(SAC)
Recurrent seizures
Idiopathic disease^[2]

Bones can be considered older in individuals with early puberty. Early puberty is marked by growth hormone problems resulting from various brain disorders.

If no cause can be identified, it is considered idiopathic or constitutional.

Peripheral Precocious Puberty

Causes can include:

Endogenous sources
- Gonadal tumors (such as arrhenoblastoma)
- Adrenal tumors
- Germ cell tumor^[3]^[4]
- Congenital adrenal hyperplasia
- McCune–Albright syndrome
Exogenous hormones
- Environmental exogenous hormones
- As treatment for another condition

Genetics

central precocious puberty

IT is caused by a mutation in the MKRN3 gene ( makorin ring finger protein 3 ) </ref>^[5]

Idiopathic central precocious puberty disease

IT is caused by a mutation in the^[6]

KISS1\KISS1R (Kisspeptin)
LIN28B (Lin-28 Homolog B)
LIN28A (Lin-28 Homolog A)

eferences

↑ PMID 15349080 (PMID 15349080)
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↑ Tommiska J, Sørensen K, Aksglaede L, Koivu R, Puhakka L, Juul A; et al. (2011). “LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty”. BMC Res Notes. 4: 363. doi:10.1186/1756-0500-4-363. PMC 3184284. PMID 21939553.
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↑ PMID 15339200 (PMID 15339200)
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↑ Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC; et al. (2013). “Central precocious puberty caused by mutations in the imprinted gene MKRN3”. N Engl J Med. 368 (26): 2467–75. doi:10.1056/NEJMoa1302160. PMC 3808195. PMID 23738509.
↑ Tommiska J, Sørensen K, Aksglaede L, Koivu R, Puhakka L, Juul A; et al. (2011). “LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty”. BMC Res Notes. 4: 363. doi:10.1186/1756-0500-4-363. PMC 3184284. PMID 21939553.

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[1] PMID 15349080 (PMID 15349080)
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[pmid219395532-2] Tommiska J, Sørensen K, Aksglaede L, Koivu R, Puhakka L, Juul A; et al. (2011). “LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty”. BMC Res Notes. 4: 363. doi:10.1186/1756-0500-4-363. PMC 3184284. PMID 21939553.

[3] Template:Cite doi

[4] PMID 15339200 (PMID 15339200)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand)

[pmid23738509-5] Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC; et al. (2013). “Central precocious puberty caused by mutations in the imprinted gene MKRN3”. N Engl J Med. 368 (26): 2467–75. doi:10.1056/NEJMoa1302160. PMC 3808195. PMID 23738509.

[pmid21939553-6] Tommiska J, Sørensen K, Aksglaede L, Koivu R, Puhakka L, Juul A; et al. (2011). “LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty”. BMC Res Notes. 4: 363. doi:10.1186/1756-0500-4-363. PMC 3184284. PMID 21939553.

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