Primary amyloidosis CT scan

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]Sabawoon Mirwais, M.B.B.S, M.D.[3] Shyam Patel [4]

CT scan can be done to assess for amyloid deposition in particular organs. It can also be done to rule out other causes of organ dysfunction. However, MRI is more sensitive than CT in the diagnosis of amyloidosis.

In hepatic amyloidosis, CT scan findings may include:

• Liver enlargement with heterogeneous decreased attenuation
• Asymmetric and triangular hepatomegaly with the apex at the falciform ligament (due to mild atrophic change of the lateral border of both hepatic lobes)
• Parenchymal calcification (rare)

In renal amyloidosis, CT scan findings may include:

• Kidney enlargement with heterogeneous decreased attenuation
• Parenchymal calcification (rare)

In cardiac amyloidosis, CT scan findings may include^[1]:

• Heart enlargement with heterogeneous decreased attenuation
• Cardiac calcifications
• Pericardial effusion (rare)

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