Primary amyloidosis other imaging findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]

Overview

Tissue doppler echocardiography and myocardial strain rate imaging has been shown to be very sensitive for the assessment of myocardial dysfunction in restrictive cardiomyopathy. The development of serum amyloid P component (SAP) scans has given physicians the ability to specifically locate amyloid deposits.

Other Imaging Findings

In addition, all amyloid deposits contain serum amyloid P component (SAP), a circulating protein of the pentraxin family. Radionuclide SAP scans have been developed which can anatomically localize amyloid deposits in patients.^[1]
Tissue doppler and myocardial strain rate imaging has been proven to be very sensitive for the assessment of myocardial dysfunction in restrictive cardiomyopathy. Doppler studies may show abnormal wall motion early in the disease process.
Abdominal ultrasound may reveal a swollen liver or spleen.
Thyroid ultrasound can help diagnose thyroidal involvement by amyloidosis.

References

↑ Pepys MB, Gallimore JR, Lloyd J, Li Z, Graham D, Taylor GW; et al. (2012). “Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use”. J Immunol Methods. 384 (1–2): 92–102. doi:10.1016/j.jim.2012.07.013. PMC 4068106. PMID 22867744.

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[pmid22867744-1] Pepys MB, Gallimore JR, Lloyd J, Li Z, Graham D, Taylor GW; et al. (2012). “Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use”. J Immunol Methods. 384 (1–2): 92–102. doi:10.1016/j.jim.2012.07.013. PMC 4068106. PMID 22867744.

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