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Primary amyloidosis physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]

Overview

Common findings in primary amyloidosis include petechiae, ecchymosis, parotid gland enlargement, increased intraocular pressure, enlarged tongue, hepatomegaly, carpal tunnel syndrome, and Raynaud’s phenomenon.

Physical Examination

Vitals

Skin

  • The most common skin findings are
    • Petechiae (small red blood spots).
    • Ecchymoses (small, flat blood spots that are round or irregular shape and bluish/purplish in colour)
    • Waxy papular nodules can be seen around the eye lids, neck and also in the groin.
    • Brittle nails.
    • Edema due to heart failure
    • Patches of hair loss can be seen.
  • Nail dystrophy
  • Cutis laxa[1]

Ear

Eyes

  • Raised intraocular pressure may be present.
  • Peri-orbital purpura[1]

Throat

Abdomen

Extremities

Macular Amyloidosis

Nodular Amyloidosis

References

  1. ↑ 1.0 1.1 1.2 Wechalekar AD, Gillmore JD, Hawkins PN (June 2016). “Systemic amyloidosis”. Lancet. 387 (10038): 2641–2654. doi:10.1016/S0140-6736(15)01274-X. PMID 26719234.

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