Primary biliary cirrhosis classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2] Anmol Pitliya, M.B.B.S. M.D.[3]
Overview
There is no established system for the classification of primary biliary cirrhosis. However, it can be classified into four stages according to histological classification of Ludwig. It can also be classified into four stages according to the histological classification of P. Scheuer.
Classification
- There is no established system for the classification of primary biliary cirrhosis.
- However, it can be classified into four stages according to histological classification of Ludwig. According to Ludwig classification, all four stages may be present on a single liver biopsy.[1][2]
- It can also be classified into four stages according to the histological classification of P. Scheuer.[3]
| Classification of Primary biliary cirrhosis on the basis of histology | ||
|---|---|---|
| Stage | Histologic appearance | |
| Ludwig classification | Scheuer’s classification | |
| Stage 1 | Portal inflammation | Florid duct lesion or chronic non-suppurative destructive cholangitis |
| Stage 2 | Extension of inflammation beyond portal tracts into surrounding parenchyma with or without ductal loss | Proliferation of the small bile ductules |
| Stage 3 | Presence of fibrous septa linking adjacent portal tracts | Fibrosis or scarring |
| Stage 4 | Cirrhosis | Cirrhosis |
References
- ↑ Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ; et al. (2009). “Primary biliary cirrhosis”. Hepatology. 50 (1): 291–308. doi:10.1002/hep.22906. PMID 19554543.
- ↑ Ludwig J, Dickson ER, McDonald GS (1978). “Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)”. Virchows Arch A Pathol Anat Histol. 379 (2): 103–12. PMID 150690.
- ↑ Scheuer P (1967). “Primary biliary cirrhosis”. Proc R Soc Med. 60 (12): 1257–60. PMC 1901478. PMID 6066569.
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