Primary hyperaldosteronism causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Common causes of primary hyperaldosteronism are aldosterone-secreting adenoma, bilateral hyperplasia of the adrenal glands, and ectopic secretion of aldosterone from ovaries and kidneys. Less common causes of primary hyperaldosteronism are familial hyperaldosteronism types I-III, pure aldosterone-producing adrenocortical carcinomas, and unilateral hyperplasia of the adrenal gland.
Causes
Common Causes
Common causes of primary hyperaldosteronism (PA) may be divided into:[1][2]
- Adrenal causes:
- Aldosterone-secreting adrenal adenoma (APA-benign tumor, 50-60%)
- Idiopathic hyperaldosteronism (IHA-Bilateral hyperplasia of the adrenal gland, 40-50%)
- Extra-adrenal causes
- Ectopic secretion of aldosterone (ovaries and kidneys)
Less Common Causes
Less common causes of primary hyperladosteronism include:[3][4][5]
- Familial hyperaldosteronism type I (glucocorticoid-remediable aldosteronism [GRA])
- Familial hyperaldosteronism type II (the familial occurrence of APA or bilateral idiopathic hyperplasia or both)
- Familial hyperaldosteronism type III (associated with the germline mutation in the KCNJ5 potassium channel)
- Pure aldosterone-producing adrenocortical carcinomas
- Unilateral adrenal hyperplasia
References
- ↑ “Primary aldosteronism: renaissance of a syndrome – Young – 2007 – Clinical Endocrinology – Wiley Online Library”.
- ↑ Aronova A, Iii TJ, Zarnegar R (2014). “Management of hypertension in primary aldosteronism”. World J Cardiol. 6 (5): 227–33. doi:10.4330/wjc.v6.i5.227. PMC 4062125. PMID 24944753.
- ↑ “Primary aldosteronism: renaissance of a syndrome – Young – 2007 – Clinical Endocrinology – Wiley Online Library”.
- ↑ So A, Duffy DL, Gordon RD, Jeske YW, Lin-Su K, New MI, Stowasser M (2005). “Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity”. J. Hypertens. 23 (8): 1477–84. PMID 16003173.
- ↑ Song MS, Seo SW, Bae SB, Kim YJ, Kim SJ (2012). “Aldosterone-producing adrenocortical carcinoma without hypertension”. Korean J. Intern. Med. 27 (2): 221–3. doi:10.3904/kjim.2012.27.2.221. PMC 3372808. PMID 22707896.
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