Progeria epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare hereditary disease. The incidence of Hutchinson-Gilford progeria syndrome (HGPS) is very rare. The usual age of diagnosis for Hutchinson-Gilford progeria syndrome (HGPS) ia around two to three years of age. Approximately 100 cases of Hutchinson-Gilford progeria syndrome (HGPS) have been reported in the literature till now worldwide.

The incidence of Hutchinson-Gilford progeria syndrome (HGPS) is approximately one in four to eight million births worldwide.^[1]^[2]
The incidence of Hutchinson-Gilford progeria syndrome (HGPS) in Netherlands is 1:4,000,000.^[3]

The prevalence of Hutchinson-Gilford progeria syndrome (HGPS) is approximately 1 in 20 million individuals worldwide.

Hutchinson-Gilford progeria syndrome (HGPS) commonly affects individuals of very younger age rather than older age.
The median age at diagnosis is 2.9 years overall.^[4]

Hutchinson-Gilford progeria syndrome (HGPS) usually affects individuals of the white race.

Hutchinson-Gilford progeria syndrome (HGPS) affects men and women equally but males are little more commonly affected by Hutchinson-Gilford progeria syndrome than females.
The male to female ratio is approximately 1.5:1.^[5]

↑ Hennekam RC (2006). “Hutchinson-Gilford progeria syndrome: review of the phenotype”. Am J Med Genet A. 140 (23): 2603–24. doi:10.1002/ajmg.a.31346. PMID 16838330.
↑ Doubaj Y, Lamzouri A, Elalaoui SC, Laarabi FZ, Sefiani A (2011). “[Three cases of Hutchinson-Gilford progeria syndrome]”. Arch Pediatr. 18 (2): 156–9. doi:10.1016/j.arcped.2010.11.014. PMID 21251803.
↑ Hennekam RC (2006). “Hutchinson-Gilford progeria syndrome: review of the phenotype”. Am J Med Genet A. 140 (23): 2603–24. doi:10.1002/ajmg.a.31346. PMID 16838330.
↑ Hennekam RC (2006). “Hutchinson-Gilford progeria syndrome: review of the phenotype”. Am J Med Genet A. 140 (23): 2603–24. doi:10.1002/ajmg.a.31346. PMID 16838330.
↑ Hennekam RC (2006). “Hutchinson-Gilford progeria syndrome: review of the phenotype”. Am J Med Genet A. 140 (23): 2603–24. doi:10.1002/ajmg.a.31346. PMID 16838330.