Pseudohypoparathyroidism history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]

A positive family history of pseudohypoparathyroidism is suggestive of the autosomal dominant inheritance.The most common symptoms of pseudohypoparathyroidism type 1a include short stature, short limbs, mental retardation associated with Albright hereditary osteodystrophy phenotype.

•  A positive history of hypocalcemia associated with Albright’s hereditary osteodystrophy phenotype is suggestive of pseudohypoparathyroidism.

• The most common symptoms of pseudohypoparathyroidism type 1a include short stature,short limbs,mental retardation associated with Albright hereditary osteodystrophy phenotype^[1]

• Common symptoms due to associated hypocalcemia include:
  • Paresthesias (peri-oral, extremities)
  • Muscle twitching
  • Carpopedal spasm
  • Seizures
  • Prolonged QT interval
  • Hypotension
  • Arrhythmia

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