Psoriasis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]

Overview

Laboratory findings consistent with the diagnosis of psoriasis include increased levels of Long Pentraxin 3 protein (PTX3) and elevated complement levels.

Laboratory Findings

Enzyme linked immunosorbent assay (ELISA)

In patients with severe psoriasis, increased levels of Long Pentraxin 3 protein (PTX3) can be observed in plasma and in monocytic cultures by enzyme linked immunosorbent assay (ELISA).^[1]

Serum complement levels

The following abnormalities of serum complement levels may be observed in cases of psoriasis:^[2]

Increased serum IgA
Increased C3 in phalyngeal arthropathy associated with psoriasis
Increased C4
Increased C3PA concentrations
Increased CRP concentration in sacroiliitis associated with psoriasis

References

↑ Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G (2006). “Long pentraxin 3: a marker of inflammation in untreated psoriatic patients”. Int. J. Mol. Med. 18 (3): 415–23. PMID 16865225.
↑ Vinje O, Møller P, Mellbye OJ (1980). “Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis”. Scand. J. Rheumatol. 9 (2): 97–105. PMID 6159678.

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[pmid16865225-1] Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G (2006). “Long pentraxin 3: a marker of inflammation in untreated psoriatic patients”. Int. J. Mol. Med. 18 (3): 415–23. PMID 16865225.

[pmid6159678-2] Vinje O, Møller P, Mellbye OJ (1980). “Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis”. Scand. J. Rheumatol. 9 (2): 97–105. PMID 6159678.

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