Radiation proctitis future or investigational therapies

Recent studies on chronic radiation proctitis suggested 2.12- to 7.31-fold higher expression levels of angiogenin, fibroblast growth factor 1 (FGF1), endoglin, matrix metalloproteinase (MMP)-8, urokinase-type plasminogen activator (uPA) and maspin in radiation proctitis tissues compared with normal rectal mucosa.Based on the this study, it has been concluded that Inhibitors of angiogenic factors such as angiogenin and FGF1 may be effective for treating radiation proctitis in future.^[1]^[2]

References

↑ Takeuchi, Hisashi; Kimura, Tetsuo; Okamoto, Koichi; Aoyagi, Eriko; Miyamoto, Hiroshi; Kaji, Masako; Takenaka, Hidetaka; Okamura, Seisuke; Sato, Yasushi; Kato, Junji; Okahisa, Toshiya; Takayama, Tetsuji (2011). “A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors”. Journal of Gastroenterology. 47 (1): 56–64. doi:10.1007/s00535-011-0470-2. ISSN 0944-1174.
↑ Babb RR (1996). “Radiation proctitis: a review”. Am J Gastroenterol. 91 (7): 1309–11. PMID 8677984.

Template:WH Template:WS

[TakeuchiKimura2011-1] Takeuchi, Hisashi; Kimura, Tetsuo; Okamoto, Koichi; Aoyagi, Eriko; Miyamoto, Hiroshi; Kaji, Masako; Takenaka, Hidetaka; Okamura, Seisuke; Sato, Yasushi; Kato, Junji; Okahisa, Toshiya; Takayama, Tetsuji (2011). “A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors”. Journal of Gastroenterology. 47 (1): 56–64. doi:10.1007/s00535-011-0470-2. ISSN 0944-1174.

[pmid8677984-2] Babb RR (1996). “Radiation proctitis: a review”. Am J Gastroenterol. 91 (7): 1309–11. PMID 8677984.

[1]

[2]