Radiation proctitis risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rekha, M.D., Mahshid Mir, M.D. [2]

Overview

Common risk factors in the development of radiation proctitis include include presence of inflammatory bowel disease, concurrent treatment, immunosuppression, other comorbidities and history of previous surgery.

Risk Factors

Common Risk Factors

Common risk factors in the development of radiation proctitis are the diseases that may increases the susceptibility of mucosal injury by radiation are:^[1]
- HIV^[2]
- Immunosuppresion^[3]
- Inflammatory bowel disease
- History of smoking
- Diabetes Mellitus
- Hypertension
- History of atherosclerosis
- Younger age
- Concurrent treatment
- Previous abdominal surgery
- Malnutrition
- Tumour stage
- Genotypic susceptibility to radiation toxicity

References

↑ Babb RR (1996). “Radiation proctitis: a review”. Am J Gastroenterol. 91 (7): 1309–11. PMID 8677984.
↑ Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R (1999). “The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer”. Int J Radiat Oncol Biol Phys. 44 (1): 127–31. PMID 10219805.
↑ Housri N, Yarchoan R, Kaushal A (2010). “Radiotherapy for patients with the human immunodeficiency virus: are special precautions necessary?”. Cancer. 116 (2): 273–83. doi:10.1002/cncr.24878. PMC 3409663. PMID 20014399.

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[pmid8677984-1] Babb RR (1996). “Radiation proctitis: a review”. Am J Gastroenterol. 91 (7): 1309–11. PMID 8677984.

[pmid10219805-2] Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R (1999). “The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer”. Int J Radiat Oncol Biol Phys. 44 (1): 127–31. PMID 10219805.

[pmid20014399-3] Housri N, Yarchoan R, Kaushal A (2010). “Radiotherapy for patients with the human immunodeficiency virus: are special precautions necessary?”. Cancer. 116 (2): 273–83. doi:10.1002/cncr.24878. PMC 3409663. PMID 20014399.

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