Rapidly progressive glomerulonephritis history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Overview

In rapidly progressive glomerulonephritis The most common early presentation is flulike symptoms characterized by malaise, fever, arthralgias, myalgias, anorexia, and weight loss. This is seen in more than 90% of patients. Following the prodrome, the other symptoms include abdominal pain, painful cutaneous nodules or ulcerations, and a migratory polyarthropathy. When pulmonary or upper airway involvement is present, patients complain of sinusitis symptoms, cough, and hemoptysis.

History

Patients with rapidly progressive glomerulonephritis may have a positive history of^[1]

Anuria
Oliguria
Macroscopic hematuria
Edema

Symptoms

Common Symptoms

Common symptoms of [disease] include:^[1]

Malaise
Fever
Arthralgias
Myalgias
Anorexia
Weight loss

Macroscopic hematuria
Edema
Oliguria
Cough

Less Common Symptoms

Abdominal pain
Painful cutaneous nodules or ulcerations
Migratory polyarthropathy.

Severe hematuria
Dyspnea

When the cause of RPGN is Goodpasture syndrome or vasculitis that involves the lungs (such as Wegener granulomatosis), patients may present with:

Cough
Hemoptysis
Dyspnea
Nasal bleeding, obstruction, or sinusitis.

References

↑ ^1.0 ^1.1 Jennette JC (March 2003). “Rapidly progressive crescentic glomerulonephritis”. Kidney Int. 63 (3): 1164–77. doi:10.1046/j.1523-1755.2003.00843.x. PMID 12631105.

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[pmid12631105-1] 1.0 ^1.1 Jennette JC (March 2003). “Rapidly progressive crescentic glomerulonephritis”. Kidney Int. 63 (3): 1164–77. doi:10.1046/j.1523-1755.2003.00843.x. PMID 12631105.

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