Rat-bite fever natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Severe complications such as endocarditis, myocarditis, pericarditis, pneumonia, meningitis, and focal organ abscesses may occur.

Rapidly fatal cases have been reported. Untreated RBF is associated with a mortality of 7%-10%. With appropriate antimicrobial therapy, the clinical course may be shortened and severe complications may be prevented. The outlook is excellent with early treatment. Untreated, the death rate can be as high as 25%.

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